Principles and Parameters of Molecular Robustness
نویسندگان
چکیده
A large number of molecular mechanisms exist to ensure the continued function of perturbed cells. Here we explore a range of mechanisms of molecular robustness. A theory of robustness is proposed in which mechanisms are classified into those that purge damage, and those that buffer damage. The strategy upon which a system settles, is a function of the cost of purgation, and thereby a function of population size.
منابع مشابه
A Self-Consistent Technique for the Construction and Evaluation of the Three-Parameter Corresponding States Principles
A self-consistent approach for the evaluation of the existing three-parameter corresponding states principles of non-polar fluids and the calculation of the corresponding states parameters is presented. This self consistent approach is based upon the assumption that the contribution of the third parameter to the thermophysical properties is much smaller than the contributions of the first two p...
متن کاملIn-silico prediction of Cellular Responses to Polymeric Biomaterials from Their Molecular Descriptors
In this work quantitative structure activity relationship (QSAR) methodology was applied for modeling and prediction of cellular response to polymers that have been designed for tissue engineering. After calculation and screening of molecular descriptors, linear and nonlinear models were developed by using multiple linear regressions (MLR) and artificial neural network (ANN) methods. The root m...
متن کاملDeveloping Robust Project Scheduling Methods for Uncertain Parameters
A common problem arising in project management is the fact that the baseline schedule is often disrupted during the project execution because of uncertain parameters. As a result, project managers are often unable to meet the deadline time of the milestones. Robust project scheduling is an effective approach in case of uncertainty. Upon adopting this approach, schedules are protected against po...
متن کاملA chaos-based video watermarking algorithm
The intriguing characteristics of chaotic maps have prompted researchers to use these sequences in watermarking systems to good effect. In this paper we aim to use a tent map to encrypt the binary logo to achieve a like-noise signal. This approach makes extraction of the watermark signal by potential attacker very hard. Embedding locations are selected based on certain principles. Experimental ...
متن کاملA First-Principles Study of the Interaction of Aspirin with Nitrogen-Doped TiO2 Anatase Nanoparticles
Objective(s): First-principles calculations have been carried out to investigate the interaction of aspirin molecule with nitrogen-doped TiO2 anatase nanoparticles using the density functional theory method in order to fully exploit the biosensing capabilities of TiO2 particles. Methods: For this purpose, we have mainly studied the a...
متن کامل